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A new study by Harvard Medical School investigators at Brigham and Women’s Hospital found that when we eat significantly impacts our energy expenditure, appetite, and molecular pathways in adipose tissue. They found that eating four hours later makes a significant difference in our hunger levels, the way we burn calories after we eat, and the way we store fat. Vujović, Scheer, and their team studied 16 patients with a body mass index in the overweight or obese range. Each participant completed two laboratory protocols: one with a strictly scheduled early meal schedule, and the other with the same meals, each scheduled about four hours later in the day. Results revealed that eating later had profound effects on hunger and the appetite-regulating hormones leptin and ghrelin, which influence our drive to eat. Specifically, levels of the hormone leptin, which signals satiety, were decreased across the 24 hours in the late eating conditions compared to the early eating conditions. When participants ate later, they also burned calories at a slower rate and exhibited adipose tissue gene expression toward increased adipogenesis and decreased lipolysis, which promote fat growth. Notably, these findings convey converging physiological and molecular mechanisms underlying the correlation between late eating and increased obesity risk.

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